The French defender has been out of action with a hamstring injury since early January but has now returned to full fitness and could start in the Round of 16 first leg in Ukraine.
City have had some injury woes of late, which forced Manuel Pellegrini to make nine changes to the line-up that lost to Chelsea in the FA Cup on Sunday, but the Chilean has revealed that centre-back Mangala is expected to be right to play which eases some of the pain.
"We have similar squad that we played in the last Premier League game (against Tottenham) - the only player that has recovered is Mangala," said Pellegrini.
"We had to make a difficult decision against Chelsea but it was the only choice we could make in this moment because we had just 13 players.
"We had to take a chance but this is absolutely different - we will try to continue knowing we have a difficult game tomorrow.
"The important thing is the performance. It's the first 90 minutes of a 180 minute match, no matter what happens, it's not over tomorrow."
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