Keane was in the Sky Sports studio working as a pundit for the game.
And after watching Mikel Arteta's fall to 14th with the 2-1 defeat, Keane cheekily suggested the Gunners had enough firepower to avoid relegation this season.
He said: "There's a softness to Arsenal now. I think they're lacking a little bit of confidence, they're lacking goals - but a huge result for Wolves.
"I think a lot of the players aren't good enough, I think there is a softness there. A few weeks ago, all the cheerleaders were out when they had a decent performance up at (Manchester) United.
"They've had one point since then and lost the other two games. I think they're soft. They're probably lacking a bit of confidence.
"I didn't see that real fight that the manager was talking about. I didn't see that desire, that determination to get a result.
"You can have an off night, of course, but you still find a way to get a result. At this moment in time, I don't see that from this group of players. I think they look a bit soft.
"I still think they'll have enough to stay up. I think they'll be strong enough to stay in the division!"