The two sides face off against each other at the weekend, with City looking to all but end Chelsea's title hopes.
And there is a possibility that De Bruyne will recover from a knee injury to face Maurizio Sarri's side. But Guardiola will let the player decide if he is fit enough.
The Spaniard is quoted by the Evening Standard as saying: "I don't know (if he will be ready). He's started training, but it's day by day.
"In this kind of situation it is the player himself who decides if he feels good. He will train with the team and we will see."