Klopp feels last night's 4-0 defeat to Manchester City reinforces the fact his players must remain fully focused to "achieve something special."
The newly crowned champions will be looking to bounce from a disappointing display at the Etihad when they host struggling Aston Villa this weekend.
"We didn't lose a lot of games in the last two and a half years. But we have lost, and so far we've always used that for the next games," Klopp said.
"If you think about things we didn't do well, in this department we have to show a reaction. That doesn't mean changing everything, it means being spot on in these moments. You cannot switch off.
"If we want to achieve something special, the only way to do that is by being 100 per cent in that specific game, which means in all the specific situations.
"Do we have to lose 4-0 to learn that? I'm not sure. But it can help. It makes the point absolutely clear."