Heskey has taken temporary charge of the club's women's team following the departure of Jonathan Morgan.
Leicester sit bottom of the Women's Super League table having lost all eight of their matches so far this season.
Morgan, who led the Foxes to promotion from the Championship in April, assistant manager Michael Makoni and first team coach Holly Morgan have all left the club.
Former Leicester striker Heskey is the club's head of women's football development and he will oversee preparations for the Continental Cup clash against Manchester United on December 5 while the search for a new manager begins.
Heskey is a legend at Leicester after coming through the club's academy and spending six years as a first team player before leaving for Liverpool in 2000.
Need a VPN? Or seeking to switch? Then support Tribal Football by clicking here to sign up with our official partners NordVPN. Not only will you receive the best VPN experience, but also great discounts by signing up via Tribal Football. Thanks for your support!