Barcelona boss Ronald Koeman's first El Clasico will take place on October 25.
La Liga have released their fixtures for the 2020/21 season, with the first round on September 13.
The second clash between Real Madrid and Barcelona will take place on April 11.
Other notable fixtures include the first Madrid derby on 13 December, with the return tie on March 7.
The season kicks off with a Valencia derby between Valencia and Levante in two weeks time.
Click here to view the full fixture list.