Mitrovic has never scored, or been on the winning side, in three games against Newcastle since he left St James' Park for £27million in 2018.
The 28-year-old was seen with heavy strapping on his right ankle after Serbia's win in Norway, but he hopes to play, knowing a win could move Fulham into the top four.
“I think he's our biggest player," said Fulham goalkeeper Bernd Leno, who has been impressed by Mitrovic's all-round game. “Not only with his goals, the way he keeps the ball, he's the first player pressing.
“I am very impressed with him. I knew he was good, but I have been impressed by how good he really is. He's a good goalscorer, he can keep the ball, he can score a goal out of nothing and we are very happy to have him in our team."