Chelsea striker Fernando Torres and Barcelona midfielder Andres Iniesta struck for Spain in their 2-0 win over Bolivia.
In two weeks' time the reigning world champions must once again butt heads with Holland - the nation they famously defeated after extra-time in Johannesburg four years ago.
Time is therefore running out for several peripheral players to prove themselves worthy of a seat on the plane to Brazil.
To that end coach Vicente del Bosque made seven substitutes during the second half and, after the outgoing Torres notched the opener from the penalty spot, substitute Iniesta contributed a clever side-footed finish in the 84th minute of play at the Ramon Sanchez Pizjuan.
