The Sydney Morning Herald reported on Tuesday that Mariners owner Mike Charlesworth was in talks with the Premier League club about a takeover.
"The chairman has held discussions with a number of clubs and interested parties across a number of years regarding the sale of the club," Mielekamp said.
"Speculation is nothing more than speculation.
"And it's important, like in the preseason, none of this distracts anyone at the club. It is just noise.
"Reports like this simply serve as a means of distraction from what is a positive season on the field."
The Mariners' connections with Manchester United include assistant coach, Mike Phelan, who was appointed sporting director of Central Coast in late 2018.