The reigning European and German champions head to the Emirates Stadium on February 19 for the first leg of the knockout stage and Muller suggests the Bavarians may have their work cut out for them in north London.
"The Gunners play a very beautiful football, they are the most difficult opponent we could have got," Muller told Kicker.
"We are on eye-level with this top team from the Premier League.
"We have had more success on national and international level than Arsenal in the last few years, that's why we are slight favourites.
"We are holders and we have improved. Of course, we are the team to beat when it comes to the [Champions League] title."
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