Barcelona will face Athletic Bilbao in the last 16 of the Copa del Rey while Real Madrid have been paired against Sevilla.
There is also guaranteed to be a second division team in the quarter-finals after Alcorcon and Cordoba were drawn against each other, but it is the two heavyweight showdowns that catch the attention.
The full draw for the last 16 is:
Las Palmas v Atletico Madrid, Alcorcon v Cordoba, Athletic Bilbao v Barcelona, Real Madrid v Sevilla, Real Sociedad v Villarreal, Deportivo La Coruna v Alaves, Valencia v Celta Vigo and Osasuna v Eibar.
The ties will be played in the first two weeks of January.