The striker could make his first league appearance since November during Sunday's match with Espanyol at the RCDE Stadium.
"Costa has been out for a long time, but when he returns he brings us energy, hunger and strength," Simeone said in his pre-match press conference.
"It's everything [Alvaro] Morata gives us.
"Joao Felix is returning too.
"We need him to get more match sharpness to be able to give the team more attacking options.
"His talent is undoubtable.
"[Angel] Correa gives us passion, goals, hard work, balance and hunger to play for the team, which is the most important thing for a footballer."