Simeone doesn't believe the officiating caused his side's defeat.
He congratulated Real Madrid and dismissed the notion that the refereeing made the difference.
"Atletico Madrid lost because of a convincing opponent," he said after the match. "I don't usually speak about VAR and I believe it's something that will surely get better and make things more efficient for all.
"I can't see the replays like those working with VAR do, so I hope they were correct with the decisions.
"I definitely don't think we lost because of VAR.
"The opposition were better than us and more convincing.
"They had a very good game.
"So we congratulate them and prepare for the next one."