The pair have responded with six goals between them - three apiece - in Wigan's first seven games of the campaign.
"We have developed a good partnership so far, even though we have not been team-mates for long," Di Santo told the Wigan Observer.
"That is good for me and it is good for Arouna, because it's always good when you can play alongside another player as well as by yourself.
"It is clear that our play compliments each other. When one of us gets the ball, the other is already starting their run because we know what's going to happen.
"You saw that with the second goal against Everton last week. He did well down the wing and his first thought was to look up and play me in.
"It also helps the team, because when your strikers are in a good moment together it can only help performances and results."