The Tottenham boss saw his side hold the league leaders to a 1-1 draw at White Hart Lane today which has them sitting five points ahead of reigning champions Manchester City.
With 15 matches remaining in the campaign, it is still far too early to tell, but Villas-Boas feels that Sir Alex Ferguson's United may have the edge in bringing home another league title.
"It is very tight between them," he told Sky Sports after the match.
"They are two strong teams with top quality squads and individuals. I think it is for either of the Manchester teams as the distance to third place is quite important.
"I'm not sure (who will win the league) but United have the experience that can help them."