Chelsea's 100% start to the season ended in a 3-1 defeat at Wigan, Manchester United were 2-0 winners at Stoke City and Tottenham and Liverpool hit five and six respectively. For Wigan it had been a long wait, 35 matches, but they finally claimed three points off a top four club with a stunning 3-1 victory at home to ten man Chelsea.
Titus Bramble headed the Latics into an early lead only for Didier Drogba to level at the start of the second period.
But the visitors were reduced to 10 men with keeper Petr Cech seeing red for felling Hugo Rodallega.
The Latics forward then beat replacement Hilario from the resultant penalty.
Wigan completed the scoring in the closing moments with Paul Scharner.
It was all square at the interval but two second half goals at Stoke City gave Manchester United the three points to return to the top of the Premiership.
Substitute Ryan Giggs crossed for Dimitar Berbatov's opener then curled in a superb free-kick which John O'Shea glanced home.
Fernando Torres hit three as Liverpool trounced struggling Hull City 6-1.
Torres opened the scoring only for Geovanni to quickly restore parity but after that the Spaniard stole the show. Steven Gerrard and Ryan Babel were the other Reds goalscorers.
Burnley's miserable form on the road continued as they slumped 5-0 at Tottenham, with Robbie Keane hitting four.
The Republic of Ireland striker hit three in the second half with Jermaine Jenas also on the scoresheet.
There were two late goals at Birmingham who seemed to have rescued a point against Bolton when Kevin Phillips equalised Tamir Cohen's first half strike with six minutes remaining.
But within four minutes Wanderers substitute Lee Chung-Yong snatched a late winner to claim the three points.
Blackburn climbed out of the bottom three the hard way.
Down to ten men and holding out for a draw to high flying Aston Villa at Ewood Park they snatched a last minute win through a David Dunn penalty.
Villa took an early lead through Gabriel Agbonlahor but Christopher Samba equalised before half time.
Vince Grella saw red on 68 minutes but Dunne sealed the points after Richard Dunne handled.
