The East Londoners head to White Hart Lane on Sunday without a win in eight away league games, failing to score in their last four, but Villas-Boas is not taking them lightly.
"They are still a very objective and aggressive team," AVB said of Andy Carroll's absence.
"They are very direct and we know what to expect against them. We will have to be alert at set plays, crosses into the box and make the play very, very strong.
"We were successful against them last season, winning home and away, and we are highly motivated for the game against West Ham.
"A London derby is always difficult, so it will be an extremely difficult match."
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