Chelsea, who are a point ahead of Spurs, take on Swansea on Sunday - less than 72 hours after they play Basle, the team who knocked Spurs out of the Europa League.
Having up to three more games to play during a tight run-in could be seen as a disadvantage for Chelsea, but their former manager disagrees.
"For me it's an advantage when you are at the door of a European final," said Villas-Boas, who won the Europa League with Porto in 2011.
"It's a fantastic final. Obviously for Chelsea they are in it because they have been knocked out of the Champions League. It's not their ambition, not what they strive for.
"But they have done well to make the semi-finals. We would prefer to play that amount of games. It's something they have to cope with. They have a big, big squad."