"I do not think I am saying anything wrong in that Wigan is a bigger game than Red Star," said the veteran midfielder. "That's obvious when you look at our league position. We have got to take points off the teams in and around us.
"It is a boost doing well in Europe. Hopefully we can take that into the league."
Manager Gary Megson opted to leave most of his key players at home to train under coach Archie Knox rather than ask them to travel to Serbia.
It could be a much-changed side again tomorrow against a Wigan team now managed by former Birmingham boss Steve Bruce.
Speed said: "The boys sitting at home will have seen our game in Belgrade and hopefully they will get a boost as well.
"However, Wigan have got a new manager and they will have had a lift.
"That makes it a very difficult game for us. It seems to happen when a new manager comes in.
"Steve has had an effect on Wigan straight away. They got a good point against Man City and their confidence will have been boosted.
"He is an experienced manager. He has been in this position before and he knows what to do.
"Steve is a wily character and will have his team well prepared for this match."