Ferguson's team have won every game in which the 29-year-old Dutchman has scored on their rise to the Premier League summit.
"I don't think it's a problem relying on Robin," he said.
"Last year, we lost (the title) on goal difference. I don't expect us to lose on goal difference again."
"Van Persie is experienced," added Ferguson.
"He had eight years at Arsenal and that helps. He has come to us at the right time."