"We want to win the title so we have to get three points there," Ronaldo said. "I don't know if it is tough for them at the moment but they will still have 11 players, the same as us, and I know it will be difficult because it always is.
"But we have a great spirit and we are a great team, so our aim is to pick up three points."
While United had an excellent record at Highbury, they have so far managed just one point from two visits to the Emirates, conceding late goals on both occasions.
"It is a new stadium and maybe it is because of that our record at the Emirates is not as good as it was at Highbury," Ronaldo added.
"But do not forget also Arsenal have great talent. We respect them and it is going to be difficult to win there."