"We have to look to win," Spalletti said. "If Inter win it will be almost unassailable, but if we triumph we will be the team who can worry them.
"They are stronger physically, but we need to play our football. We know the way it will be - they will try and manage the game like usual, but we have been able to disrupt them in the past."
Roma also face Real Madrid next week and Spalletti added: "The next two games are crucial and we are ready to compete physically and mentally. Lots of players seem rested, everything is in order and we are ready to go."