Marcos Rojo and Andreas Pereira will play for Manchester United's U23 side on Friday night.
The senior duo will line-up for Ricky Sbragia's outfit against West Bromwich Albion U23s at Old Trafford.
Argentina international Rojo has made four first-team appearances in 2018/19 due to injury, but could be recalled soon with Luke Shaw suspended for the next two league games.
Pereira has came off the bench in United's last two matches against Watford and Wolves.