Three regular starters have been 19-year-old Andre Wisdom, 17-year-old Raheem Sterling and 18-year-old Suso.
Reina has no doubt they will relish performing within one of football's most intense atmospheres.
"I'd tell them to just play as they are doing right now," the Spanish goalkeeper told liverpoolfc.com.
"The test for them was Stoke at home. It was quite a physical game and they coped well. A derby? [Because they have come through the Academy] They know what it means for the club and for the supporters to win this game, and they will be very up for it.
"They will handle the pressure, I have no doubt. They will cope with it well, they will be aggressive. They are ready for this game and if not we're right behind them to get them on track."