The Rs need a result to guarantee staying up - while City must win to be sure of keeping the title away from Manchester United's clutches.
"We haven't covered ourselves in glory this year on the road, but what better time to turn it around?" Hughes said.
"There will be a huge amount of expectation on the game with them going for the title, but we'll give it our best shot.
"It's unbelievable what this league throws up time and again, but it's in our hands and that's all we can ask for.
"Obviously results elsewhere could help us out, but we want to go and make it happen ourselves.
"My focus is totally on what we do - I get the feeling we'll be a lot better than we were at Chelsea last week."