The Gunners remained fifth on the table despite their 4-1 home win over Reading which came courtesy of goals from Gervinho, Santi Cazorla, Olivier Giroud and Mikel Arteta whilst Hal Robson-Kanu was on target for the Royals who remain rock bottom of the table.
City returned to form following their defeat to Everton recently by cruising past Newcastle United 4-0 at the Etihad Stadium with Carlos Tevez, David Silva, Vincent Kompany and a James Perhc own-goal doing the damage.
United maintained their 15-point lead on rivals City due to a narrow 1-0 win at Sunderland thanks to Titus Bramble's first-half own-goal and could now put themselves 18 clear if they happen to win the Manchester derby next Monday.
Elsewhere, Southampton surprised Chelsea 2-1 at St Mary's to move up to 12th, Andy Carroll's double allowed West Ham United to beat West Bromwich Albion 3-1 in East London and Wigan Athletic moved out of the drop zone with a 1-0 home triumph over Norwich City.
Gareth Bale scored his eighth goal in his past eight outings (for a season tally of 17) and also set up Jan Vertonghen's opener as Tottenham beat Swansea City 2-1 in South Wales, Everton stayed sixth with a 1-0 victory over Stoke City, Liverpool came from behind to edge Aston Villa 2-1 on Sunday and Fulham heaped more misery on QPR with a 3-2 result at Craven Cottage on Monday night.
2012/13 Barclays Premier League season scores
Fulham: 3 (Dimitar Berbatov (p) 8'/22', Clint Hill (og) 41', red card: Steve Sidwell 79') Queens Park Rangers: 2 (Adel Taarabt 45', Loic Remy 51', penalty miss: Remy 49') Craven Cottage, London - 25,117