Former QPR and Manchester United defender Paul Parker says the Premier League leaders will be tested at Loftus Road.
Parker, who moved north from the capital in 1991, believes things may be awkward for United's wide players - the likes of Nani, Antonio Valencia and Ashley Young - if they are selected in the starting line-up.
"It's very tough at QPR as it's a small ground and it helps them," the 48-year-old told ManUtd.com. "I tell you why they keep so many clean sheets there: it's because if a team's great strength is out wide then it kills them.
"It's why wingers have always struggled at QPR. The only player with any width who did well in my time there was Andy Sinton but that's because he had other things about him rather than staying on the touchline. It's a very narrow pitch. It's as simple as that and it's very easy to defend there."