The Eagles know a victory would put them five points clear of their opponents, who currently occupy the final relegation place in the English Championship.
A win for the Blades, however, would lift them above Palace and dump Freedman's side back in the drop zone.
"It is a big game - but it is a big game for them as well," said Freedman.
"They need to come here and not be beaten. It is a game we are all looking forward to."