Several of Mikel's team-mates have applauded the move and, having returned from suspension to play Boxing Day's 1-0 win at Norwich alongside Luiz, it appeared less of a concern for the Nigerian ahead of Sunday's trip to Everton.
"It affects you because I've been here for a long time," said Mikel, who has become used to lining up with Frank Lampard or Ramires.
"I've always played with Frank and now I've played with Rami as well - they're all great players. And now I have to play with David Luiz.
It's just a lot. It's a lot, I think, psychologically as well. You think, 'If I'm playing today, who am I going to play with?' - because they're all great players.
"I've played with Frank for a long time and I've always enjoyed playing with Frank, and Rami as well, and [now] with David."