The two teams played out a 1-1 draw in the first leg in Belgium last week, and a win would be enough for United to progress into the semi-finals of the competition.
Nicholas is backing the Swedish striker to score the first goal in a 2-0 United win at Old Trafford.
The pundit writes in his Sky Sports column: "First of all, what a result for United at the weekend.
"We were blessed to get Jose Mourinho on Soccer Saturday having a chat with Jeff Stelling. He seemed like he was at the end of the world with injury problems and not being happy with his strikers, but he gets a big result when they needed it.
"They've got a big group and they're obviously not all players Jose likes, but he got it bang on with his changes on Sunday and he'll be able to bring a fresh Zlatan Ibrahimovic back in.