While happy with Pique's late goal, his taunting of the home crowd left Messi unimpressed.
Pique's actions only raised the intensity of Espanyol's players and fans, with the game descending into a melee at the final whistle.
Don Balon says the veteran defender will always have Messi's public support, but behind closed doors he's made it clear Pique's actions are hurting the team.
When the players reassembled in the away locker room, Messi was the most vocal against Pique for his taunts. But the protests fell on deaf ears, with the defender continuing his mocking of Espanyol in his post-match interview.