The league-leading Red Devils travel to Stoke City on Saturday but the central defender is in doubt with a calf strain. Ferguson hopes he can play as he is aware of the dangers his side faces at the Britannia Stadium.
"I'm hoping Rio will be OK for Saturday," he told the club's official website.
"When you go to Stoke you need a bit of experience.
"Rio came into the team when we played at Bolton and gave us that experience, so we hope he'll be fit for Saturday."