Manchester United will be without forwards Antony, Jadon Sancho and Anthony Martial against Real Sociedad in the Europa League.
Sancho is ill while Martial, who has not featured since 9 October, and Antony are still recovering from injury.
United will finish top of Group E if they win by two goals or more in Spain.
That will send them into the last 16, otherwise they face a two-legged knockout round play-off in February.
Red Devils boss Erik ten Hag said Cristiano Ronaldo is likely to start against Real Sociedad, who top Group E going into the final round of games on 15 points, three more than United.
"Ronaldo is an important part of this group and a leader type," added Ten Hag.