Mancini fined Balotelli for visiting a strip club less than 48 hours before their win over Bolton Wanderers.
"Do I think he's more trouble than he's worth? No. I have a lot of patience with him," said Mancini.
"Probably he gets bored quickly. There is no malice. He just doesn't think that there is a game in two days, that players are away on international duty and that we prepare for him to be the main striker because he would be freshest.
"He doesn't think along those lines, but this has to change."