Pep Guardiola confirmed Sergio Aguero will miss Manchester City's match with Brighton as he is still in quarantine, reports Sky Sports.
Aguero missed Sunday's FA Cup third-round victory over Birmingham after being asked to isolate as a close contact of someone who has tested positive for Covid-19.
It is yet another setback for the striker, whose return from knee surgery this season has already been complicated by further pain in the joint and a hamstring injury.
The 32-year-old, who has not started a game since October, had been expected to feature last weekend.