Benitez was named coach of Napoli this week.
Chiellini said: "I consider Benitez to be a great Coach, but it won't be easy replacing Mazzarri. He must win the Scudetto and go forward in the Champions League. His career reflects his talents and I think Napoli can make a real impact.
"Italian football will be curious to see Benitez at work after a few difficult months at Inter, arriving after Jose Mourinho had won everything."