Melo saw red during the game.
And Zaccheroni said: "In the second half when Diego started to go wide a bit more and didn't remain rooted to the centre, we became dangerous.
"He should start as a trequartista between the lines and find the space, tying the midfield and strikers together. I expect him to release Amauri and Del Piero. Amauri is forced to play with his back to goal and we need to move the ball around so he can face the target."
Melo was sent off in the final minutes for a second bookable offence.
"Melo is a lad who can't bear to lose and always gives everything he's got, which unfortunately means he picks up early cards and they affect the rest of his game.