Inter Milan have suffered a double injury blow ahead of their Champions League tie at Tottenham.
The two Nerazzurri players picked up injuries during Friday night's 1-0 win away to Genoa.
Both Julio Cesar and Cambiasso suffered muscular setbacks and are not even making the trip to London.
This means Luca Castellazzi will have to take the gloves at White Hart Lane on Tuesday.
Dejan Stankovic, MacDonald Mariga, Thiago Motta and forward David Suazo are all out of action.