Inter goalkeeper Julio Cesar and Esteban Cambiasso are out.
The two Nerazzurri players picked up injuries during Friday night’s 1-0 win away to Genoa.
Both Julio Cesar and Cambiasso suffered muscular setbacks and are not even making the trip to London.
This means Luca Castellazzi will have to take the gloves at White Hart Lane on Tuesday.
Cristian Chivu and Diego Milito return, but the midfield is particularly hard hit by absentees.
Dejan Stankovic, MacDonald Mariga, Thiago Motta and forward David Suazo are all out of action.