Following their solid away win at Newcastle, the Seasiders were brushed aside by the country's most in-form team who scored all four goals in the first half.
Salomon Kalou got proceedings under way by finishing at the back post after Branislav Ivanovic had flicked on Didier Drogba's corner in the 2nd minute before Florent Malouda got in on the act ten minutes later, firing home after Drogba teed him up.
The Ivory Coast striker then got one for himself in the 30th minute before Malouda essentially wrapped up the contest four minutes before half-time, finishing good lead-up work from both Drogba and Kalou.
The win maintained the Blues' near-perfect start to the season with 22 goals in their five wins and enabled them to go four points clear of second place.
Venue: Stamford Bridge - Fulham, West London Crowd: 41,761 Referee: Mark Clattenburg Yellow cards:CH - Didier Drogba 37' BL - Neil Eardley 38', David Vaughan 54'
CH Petr Cech (gk), Branislav Ivanovic, Alex (Bruma 72'), Ashley Cole, Paulo Ferreira, John Obi Mikel (Benayoun 78'), Ramires (Zhirkov 75'), Michael Essien, Florent Malouda, Didier Drogba, Salomon Kalou
Subs - Ross Turnbull (gk), Nicolas Anelka, Yossi Benayoun (78'), Yuri Zhirkov (75'), Daniel Sturridge, Gael Kakuta, Jeffrey Bruma (72')
BL Matthew Gilks (gk), Ian Evatt, Dekel Keinan, Stephen Crainey, Neil Eardley (Taylor-Fletcher 46'), Charlie Adam, David Vaughan, Alex Baptiste, Luke Varney (Ormerod 62'), Eliot Grandin (Harewood 61'), DJ Campbell