He picked up the injury after standing on a water bottle while celebrating England's 37th-minute leveller - and was even carried off on the stretcher usually reserved for his players and will fly back to England.
Roy Hodgson's staff jumped off the bench in celebration but Lewin, who will be replaced by Steve Kemp for the remainder of the tournament, immediately fell to the floor and repeatedly banged the ground with his fist.
"That was a very sad moment for us," England boss Roy Hodgson said. 'In celebrating the goal he jumped up, landed on a water bottle and dislocated his ankle.
"It was very painful. He was taken to hospital. The doctor set it, put it back in at the side of the field, but it's the end of the World Cup for Gary."
In 2007, Lewin was credited with possibly saving John Terry's life in the League Cup Final after the Chelsea captain swallowed his tongue and Lewin, then Arsenal physio, was first off the bench to assist him.
During his time at Arsenal he was also credited with saving striker Eduardo's career after he suffered a horror leg break.
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