The Frenchman has not had much luck against the Blues in recent times, being a part of an ugly post-match brawl as well as enduring injuries and close attention from Chelsea players.
But this Sunday he is looking to get some back and inflict defeat on the Blues.
"If you ask me for the one game that I want to win above all others each season it's the game at Chelsea," said Evra.
"They're our biggest rivals for the title so we need to be strong. It's a long time since we won there so it's about time we put that right.
"Every time I play them something bad happens. There was the trouble on the pitch after one game, then this season there was the incident with Ballack.
"I have to make sure nothing happens this time. I just want to have a good memory and enjoy playing against Chelsea.
"But I've never lost against them when I've started. We lost in the Community Shield but I never lose when I am in the team from the start, so I want that to continue."