Manchester United's woes have continued in the form of a 2-1 loss to FC Midtjylland in the Europa League Round of 32.
The Red Devils took the lead in the first leg tie at MCH Arena in Herning but could not hold onto their advantage as the Danish champions fought back well.
Jess Thorup's side drew level on the stroke of half-time before producing a 77th minute winner through Nigerian youngster Ebere Paul Onuachu to give themselves a slender lead heading into the return bout at Old Trafford next week.
Memphis Depay struck first for United in the 37th minute when he managed to control a cross from Jesse Lingard while off balance before recovering to slot home from the edge of the six-yard box.
However, Midtjylland were back on level terms seven minutes later though Denmark winger Pione Sisto.
Michael Carrick played a careless pass which was pounced on by the Ugandan-born dangerman who advanced goal-ward, tracked right to beat off the challenge of Ander Herrera, and then fired a low effort beyond Sergio Romero with help from a small deflection off Chris Smalling.
Lingard had the chance to fire United back in the lead early in the second half but blazed his 18-yard effort wide of the mark before Juan Mata was unable to place his header from an Anthony Martial cross on target.
Louis van Gaal's side were making all the play in the opening 15 minutes of the second term, and were desperately unlucky when Herrera crossed for Lingard who fired into the woodwork in what would have been a stellar team goal.
Herrera then tried his luck with a left-footed effort which moved off target as the visitors went in search of a second goal.
Down the other end, Romero pulled off a remarkable save to deny substitute Onuachu who had looped a header destined for the top corner only to see the Argentine claw it out.
Midtjylland then started to kick up a gear and came close in the 68th minute when Sisto's curling effort went inches wide, less than 10 minutes prior to the eventual winner.
Onuachu was messing about trying to get past Carrick and lost the ball briefly before stealing it back from Mata and then simply passing it beyond Romero from outside the area in nonchalant fashion.
For all their chances, United were unable to play with any efficiency as the Ulvene, who were only founded in 1999, got the better of England's most successful and well-known club on a famous night in Central Denmark.
2015/16 UEFA Europa League - Round of 32 first leg
FC Midtjylland (DEN): 2 (Pione Sisto 44', Ebere Paul Onuachu 77')
Manchester United (ENG): 1 (Memphis Depay 37')
MCH Arena, Herning, Denmark
