Defoe has been linked with a summer departure but Villas-Boas has made it clear he has a future at White Hart Lane whilst confirming that talks for a permanent move for Adebayor, who starred on loan last season, are ongoing.
"I have spoken to Jermain and his agent about the situation. The talks were positive," said AVB.
"Jermain scored 17 goals last year. He was a key player and will continue to be. That's the expectancy I have with regards to his future."
He added: "There are talks (regarding Adebayor). They have been happening for quite some time.
"We have touched on different players in that position, but we have not been able to conclude a deal.
"Our focus and attention is towards that position, which we will try to sort out next week."