With Sir Alex already confirming he'll field his strongest team at the Amsterdam ArenA, United are out to secure a commanding position ahead of next week's Old Trafford return.
"Playing at home in the second leg is important but it's only a small advantage - it doesn't guarantee victory," Hernandez told MUTV.
"It'll be a difficult game but we'll go to Amsterdam looking to win.
"The Champions League is the best competition in Europe and it's a bit strange to be in the Europa League. But we want to win every tournament we enter.
"Both teams have a lot of history in Europe, so it should be a great game."