With Sir Alex already confirming heâ€™ll field his strongest team at the Amsterdam ArenA, United are out to secure a commanding position ahead of next week's Old Trafford return.
"Playing at home in the second leg is important but itâ€™s only a small advantage â€“ it doesnâ€™t guarantee victory," Hernandez told MUTV.
"Itâ€™ll be a difficult game but weâ€™ll go to Amsterdam looking to win.
"The Champions League is the best competition in Europe and itâ€™s a bit strange to be in the Europa League. But we want to win every tournament we enter.
"Both teams have a lot of history in Europe, so it should be a great game."