United convincingly won their opening fixture with Swansea but Chelsea have already picked up six points and are hoping to set an early precedent.
"I think it's between four or five big teams to challenge, but these games are important because you don't want to drift three points behind Man United, let alone Spurs, Arsenal, Liverpool and Man City," Terry told Sky Sports.
"I don't think its going to make or break the season. It could be one of those that gives a head start for either side but we have had a good record going to Old Trafford over the last few years and I think that will serve us well.
"Obviously it's David Moyes' first game at the stadium but we're expecting a hostile atmosphere anyway."
For the big stories and the banter follow us on Twitter: @tribalfootball