Lyon president Jean Michel Aulas admits they face having to make a major sale this summer.
Nabil Fekir has been linked with Chelsea, while Manchester City are eyeing Houssem Aouar and Tanguy Ndombele.
And Aulas conceded: "We will let one player leave from those who are solicited.
"I do not know who because there are many. We made a big effort to convince Nabil to stay when it was almost certain that he could leave (for Liverpool).
"Easier to let (Memphis) Depay leave than Aouar? Yes. Houssem is scheduled to start against the champion team of Europe (Barcelona) and will be in Lyon in the years to come."