Celtic, along with Glasgow rivals Rangers, have been linked with a potential Premier League shift over the past five years or so but Mackay, who is attempting to get a second Welsh side into the top competition in England, feels it would be a bad idea.
"The fact the Welsh teams have always been involved in the English league makes it different," he told SunSport.
"I don't think Scottish clubs in England is something I'm going to see in the short term.
"As far as Celtic moving to England goes, I'm not sure it would be a good thing for Scottish football.
"Or would it be a tiny deal for the rest of the clubs?
"It would become a diluted league with a lack of finances and there might even be a lack of interest in it outwith local communities.
"With the Old Firm, most of the country wants to watch. It's simple.
"And maybe the English Premiership clubs would be against it because they look at Celtic's success in Europe - and it becomes a question of money.
"Celtic are not operating on a level playing field and I understand from a business point of view why they keep knocking on the door.
"But from a Scottish point of view, I understand why everyone else wouldn't want it to happen. You want the best teams in your country."