The 17-year-old said his performance, which included a hat-trick and two assists, was the best thing that has happened to him during his nine years at Arsenal.
"It's not every day that we play at a stadium like this and it is obviously our home ground," Afobe told arsenal.com.
"Before the game all I wanted was to win, and then maybe get one goal for myself. But I never thought of a hat-trick and two assists. It is like a dream come true!
"And I got the match ball too! I wasn't expecting that, I was just happy that we won.
"This is the best thing that has happened to me as a player at Arsenal, and hopefully more will come."