Falcao was outstanding in victory over Athletic Bilbao on Wednesday night.
"Big players run a risk because they have experience but if they can't put their past wins to one side and get excited for a final, their experience counts for nothing," Simeone declared.
"Falcao is the best example. He forgot what he did last year and because of that he could live the moment he did on Wednesday.
"I've known Radamel since he was a boy. I had him at River [Plate in 2008], where we won a league together. I love him as a person and admire him. There's no ceiling to his ambition."