Arsenal young gun Wilshere has only recently returned to club football following a 17-month injury absence whilst Everton's Osman gets his first senior call-up at the age of 31 after some impressive form for the Toffees.
Joining these two are inexperienced Liverpool pair Jonjo Shelvey and Raheem Sterling, Chelsea's Ryan Bertrand and Tottenham's Steven Caulker among the usual names such as captain Steven Gerrard, Joe Hart, Wayne Rooney and Gary Cahill.
England squad for Sweden friendly
Leighton Baines (Everton) Ryan Bertrand (Chelsea) Gary Cahill (Chelsea) Steven Caulker (Tottenham) Phil Jagielka (Everton) Glen Johnson (Liverpool) Ryan Shawcross (Stoke City) Kyle Walker (Tottenham) Midfielders
Tom Cleverley (Manchester United) Steven Gerrard (Liverpool, capt) Aaron Lennon (Tottenham) Leon Osman (Everton) Jonjo Shelvey (Liverpool) Raheem Sterling (Liverpool) Theo Walcott (Arsenal) Jack Wilshere (Arsenal) Ashley Young (Manchester United)